RNA may stop breast cancer spread

RNA may stop breast cancer spread

Now, researchers can develop more effective drugs to prevent or treat cancer metastasis, as they have identified a specific group of microRNA molecules that are responsible for controlling genes that cause breast cancer metastasis.

The study, led by scientists at Memorial Sloan-Kettering Cancer Center (MSKCC), appears in the January 10, 2008, issue of Nature.

The researchers examined human breast cancer cells with strong metastatic ability and found that the cells had lost large numbers of three different microRNA molecules. Conversely, when researchers put those molecules back into human breast cancer tumors in mice, the tumors lost their ability to spread.

In addition, the researchers looked at breast cancer patients and discovered that those with tumors that had lost these molecules were much more likely to suffer from cancer metastasis to the lung and bone.

MicroRNAs identified are
- miR-335
- SOX4
- tenascin-C

MicroRNAs are known to inhibit the activity of entire sets of genes associated with cancer metastasis - a process that leads to the majority of cancer-related deaths. The new work explains how the loss of certain microRNAs allows cancer cells to migrate through organ tissue and to grow more rapidly.

"The identification of molecules that inhibit a cell's metastatic potential may help guide clinical decision-making in the future by enabling oncologists to more accurately identify patients at highest risk for metastatic relapse," said the study's lead author Sohail Tavazoie, MD, PhD, a postdoctoral fellow in the Oncology-Hematology Fellowship program at MSKCC.

The study was co-authored by William L. Gerald, MD, PhD, a surgical pathologist and member of the Human Oncology and Pathogenesis Program at MSKCC, and by members of Dr. Massagu?'s laboratory, including Claudio Alarc?n, graduate student; Thordur Oskarsson, PhD, research fellow; David Padua, graduate student; Qiongqing Wang, PhD, research fellow; and Paula D. Bos, graduate student.

The research was funded by grants from the National Institutes of Health, the Hearst Foundation, the Kleberg Foundation, and the Olson Foundation, and a Clinical Scholars Award.

(Editor compiled and published RNA may stop breast cancer spread at HealthNewsTrack on January 13, 2008 sourced from Memorial Sloan-Kettering Cancer Center - http://www.mskcc.org/mskcc/html/83171.cfm)

Breast cancer - recent articles and current news stories:

- 2 cups of coffee protects against breast cancer recurrence
- New blood test predicts breast cancer risk
- Mammography screening for breast cancer needs individualized approach
- Yoga improves quality of life in breast cancer women
- Yoga can lower fatigue inflammation in breast cancer survivors

Most related articles:

- RNA may stop breast cancer spread
- Breast cancer drug Tykerb to be subsidised - 6.6
- High cholesterol may lead to breast cancer in post menopausal women - 5.7
- Genes spread breast cancer cells to brain - 5.5
- Breast cancer spread stopped by bone drug - 5.3

More related articles:

- RNA, Breast cancer, Cancer, Nature, Tumor, Lung, Bone, Oncology, Hematology, Health
- Breast cancer spread stopped by bone drug - 12.7
- Understanding chronic myeloid leukemia - 10.7
- Researchers decoded genetic evolution of a breast cancer tumour - 9.5
- Breast cancer's ability to relapse linked to genes - 9.2

Breast cancer related articles:

- Breast cancer drug Tykerb to be subsidised - 5.3
- Breastfeeding mothers reduce breast cancer risk - 4.9
- Breast cancer recurrence high in women with dense breasts - 4.9
- 7% breast cancer patients have breast reconstruction surgery - 4.8
- Exercise reduces breast cancer risk - 4.8

Breast cancer article/news source:

Read more health articles from Memorial Sloan-Kettering Cancer Center and health articles from USA.

Breast cancer - search related terms:

Bone, Breast cancer, Cancer, Health, Hematology, Lung, Nature, Oncology, RNA, Tumor,

Health Newstrack is dedicated to serve recent and updated health & medical research, events/news, views/reviews to its subscribers and free access to general public, health & medical professionals, and other health seekers worldwide online with a user-friendly system. Track health news daily at Health Newstrack.
Subscribe: rss | email

Top sections:
Health (189)
Breast cancer (169)
Healthcare (134)
HIV (130)
Obesity (126)
Pregnancy (115)
Diabetes (102)
Swine Flu (97)
Prostate Cancer (86)
Heart disease (86)
Smoking (81)
Alzheimer's Disease (79)
Cancer (75)
Depression (61)
Autism (53)

Current news
The identification of molecules that inhibit a cell's metastatic potential may help guide clinical decision-making in the future by enabling oncologists to more accurately identify patients at highest risk for metastatic relapse.

What is Breast cancer?
About Breast cancer -- Breast cancer is the abnormal growth and uncontrolled division of cells in the breast. Cancer cells invade and destroy surrounding normal tissue, and can spread throughout the body via blood or lymph fluid (clear fluid bathing body cells) to start a new cancer in another part of the body.

List health news, Health organizations, Health news world, Glossary     Go to top

The information provided on Health Newstrack is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician. We comply with the HONcode principles for trustworthy health information, and Health News Track is hon code accredited, verify here.
About us, Site map Privacy policy, Disclaimer
© 2015 HealthNewstrack.com
Health Newstrack - Track Health News Daily at HealthNewstrack.com. Our Newstrack on Health News provides latest health news, medical news, and health articles with recent health & medical updates.