Clinical Research

Clinical Research articles

Lithium may prevent brain damage in patients with Parkinson's disease
Researcher are focusing on lithium as a potential treatment for Parkinson's disease -- PD -- as well as its efficacy in combination with drugs currently used to control the symptoms of the disease. Lithium profoundly prevents the aggregation of toxic proteins and cell loss associated with Parkinson's disease (PD) in a mouse model of the condition.

Pfizer drug reduces breast cancer in high risk women
The drug exemestane significantly reduces the risk of breast cancer in high-risk, postmenopausal women is the result of an international, randomized double-blind phase III clinical trial in which University at Buffalo researchers and hundreds of Western New York women played a critical role, revealed at the American Society of Clinical Oncology annual meeting.

2011 award winners in pediatric otolaryngology research announced by ASPO US
The American Society of Pediatric Otolaryngology (ASPO) will recognize the outstanding achievements of researchers in the field of pediatric otolaryngology during their annual meeting, April_29 – May_1, 2011, in Chicago, IL.

New treatment with omalizumab may desensitize kids with milk allergies
Milk allergy is the most common, affecting 2.5 percent of children under age 3. In a small clinical study, researchers report effectively desensitizing milk-allergic patients by increasing their exposure to milk in tandem with an allergy drug called omalizumab, allowing children to build up resistance quickly with limited allergic reactions.

New drug approach for prostate cancer drug
A small slice of RNA inhibits prostate cancer metastasis by suppressing a surface protein commonly found on prostate cancer stem cells, revealed by researchers.

Genetic test for lung cancer risk prompts smokers to quit
New research shows a gene-based test for lung cancer risk assessment motivates smokers to quit or cut down, according to results of a clinical study presented today at the American Association of Cancer Research's Ninth Annual Conference on Frontiers in Cancer Prevention Research.

Sad depressed mothers have small babies
Clinical depression and anxiety during pregnancy results in smaller babies that are more likely to die in infancy, according to new research published in the open access journal BMC Public Health.

Clinic based HIV prevention is effective in reducing risk behaviors
Delivering HIV prevention services to people living with HIV in clinical settings can sharply reduce their sexual risk behaviors, revealed by UCSF researchers.

HbA1c accurately predicts future diabetes
Measurements of hemoglobin A1c (HbA1c) more accurately identify persons at risk for clinical outcomes than the commonly used measurement of fasting glucose, according to a study by researchers at the Johns Hopkins Bloomberg School of Public Health.

New 3 drug combination for multiple myeloma patients
A new three-drug combination has shown in a phase 1/2 clinical trial that it is a "highly effective regimen" in the treatment of patients newly diagnosed with multiple myeloma, a cancer of white blood cells in bone marrow, say researchers from Dana-Farber Cancer Institute.

Math may predict Herceptin response in breast cancer patients
Cancer researchers are turning to mathematical models to help answer important clinical questions, and a new paper in Cancer Research, a journal of the American Association for Cancer Research, illustrates how the technique may answer questions about Herceptin resistance.

Breast cancer drug Abraxane promising for malignant melanoma treatment
An approved breast-cancer drug nab-paclitaxel, trade named Abraxane, has been found promising in clinical trial for the treatment of metastatic malignant melanoma, revealed by researchers.

Rheumatoid arthritis drug masitinib found effective
A clinical trial of masitinib, a drug in development for the treatment of rheumatoid arthritis, has shown it to be well tolerated and effective, revealed by researchers in BioMed Central's journal Arthritis Research and Therapy.

$24 million for rare and neglected diseases research
The National Institutes of Health is launching the first integrated, drug development pipeline to produce new treatments for rare and neglected diseases. The $24 million program jumpstarts a trans-NIH initiative called the Therapeutics for Rare and Neglected Diseases Program, or TRND.

Omega 3 reduces prostate cancer risk
Omega-3 fatty acids appear protective against advanced prostate cancer, and this effect may be modified by a genetic variant in the COX-2 gene, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research.

Clinical trials overseas raises quality control issues
Top-tier U.S.-based pharmaceutical companies are moving their clinical trials overseas at warp speed, raising questions about ethics, quality control, and even the scientific value of their findings for people back in the U.S.

Weight loss reduces urinary incontinence in overweight obese women
Reducing urinary incontinence can now be added to the extensive list of health benefits of weight loss, according to a clinical trial funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Office of Research on Women's Health (ORWH), both part of the National Institutes of Health (NIH).

Nicole Johnson takes action for type 1 diabetes research
Diabetes in Children and Adolescents has particular urgency for former Miss America Nicole Johnson. Nicole has served as an international spokesperson for diabetes issues for more than 8 years. She has worked tirelessly promoting awareness, prevention and early detection of the hidden killer, diabetes.

Vitamin C supplements reduce benefits of anti cancer drugs
In pre-clinical studies, vitamin C appears to substantially reduce the effectiveness of anticancer drugs, say researchers at Memorial Sloan-Kettering Cancer Center.

India to develop HIV AIDS vaccine soon
A second Phase I AIDS vaccine clinical trial in India was successfully completed, the Indian Council of Medical Research, the National AIDS Control Organization and the International AIDS Vaccine Initiative announced.

Persistent HPV infection raises cervical cancer risk
Persistent infection with human papillomavirus (HPV) could be a useful clinical marker for increased risk of cervical cancer, the second most common cancer in women worldwide, revealed by researchers from the University of North Carolina at Chapel Hill.

American physicians prescribe placebos on occasion
In the first study examining American physicians' use of placebos in clinical practice in the 21st Century, 45 percent of Chicago internists report they have used a placebo at some time during their clinical practice researchers report in the January issue of Journal of General Internal Medicine.

22 Clinical Research articles listed above.

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