Gene Mutation

Gene Mutation - most related articles:

- ABCG2 gene mutation causes gout - 5.7
- Mesothelioma linked to gene mutation - 5.4
- New class of cancer drugs could work in colon cancers with genetic mutation - 5.3
- New risk factor for developing breast cancer - 5.2
- Breast cancer gene mutation common in Hispanic, young black women - 4.8
- Brain cancer malignant glioma linked to gene mutations - 4.8
- Melanoma skin cancer triggered by BRAF gene mutation - 4.4
- Gene mutations lead to autism and mental retardation - 4.2
- Zelboraf approved for late stage skin cancer - 4.2
- Human swine influenza virus mutation found - 4.1

Gene Mutation articles

Genetic changes in 3 genes linked to autism spectrum disorders
Mutations in three new genes have been linked to autism, according to new studies including one with investigators at Mount Sinai School of Medicine. All three studies include lead investigators of the Autism Sequencing Consortium (ASC).

Breast cancer risk gene can be discovered by massively parallel sequencing
A new technology is developed to fast track the discovery of a breast cancer risk gene and could assist in the discovery of other cancer genes. Now, breast cancer risk gene can be discovered using the latest genetic sequencing technology.

Cancer treatment with personalised approach to cancer patients
Recently researchers have profiled genetic changes in cancer with drug sensitivity in order to develop a personalised approach to cancer treatments. They uncovered hundreds of associations between mutations in cancer genes and sensitivity to anticancer drugs.

Understanding working of parkin gene and Parkinson's disease
Parkinson's disease researchers at the University at Buffalo have discovered how mutations in the parkin gene cause the disease, which afflicts at least 500,000 Americans and for which there is no cure. The results are published in the current issue of Nature Communications.

10% of ADHD patients linked to GMR gene variants
Pediatric researchers analyzing genetic influences in attention-deficit/hyperactivity disorder (ADHD) have found alterations in specific genes involved in important brain signaling pathways.

Autism linked to gene mutation on chromosome 16
Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered that one of the most common genetic alterations in autism -- deletion of a 27-gene cluster on chromosome 16 -- causes autism-like features.

Mesothelioma linked to gene mutation
Individuals who carry a mutation in a gene called BAP1 are susceptible to developing two forms of cancer – mesothelioma, and melanoma of the eye. Mesothelioma tumors are typically associated with asbestos and erionite exposure.

Genetic changes may lead to Barrett's esophagus and esophageal cancer
Mutations in three genes have been identified that are more prevalent in patients with esophageal cancer and Barrett esophagus, a premalignant metaplasia (change in cells or tissue) caused by chronic gastroesophageal reflux disease (GERD), according to preliminary research reported in the July 27 issue of JAMA.

New class of cancer drugs could work in colon cancers with genetic mutation
A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.

Protein may improve muscle function of muscular dystrophy
A novel potential therapy based on a natural human protein significantly slows muscle damage and improves function in mice who have the same genetic mutation as boys with the most common form of muscular dystrophy, according to a paper published online Dec._27 in the Proceedings of the National Academy of Sciences.

Parents favor genetic testing for melanoma in their children
The vast majority of parents who tested positive for a genetic mutation that increases the risk of melanoma (the most serious form of skin cancer) support genetic testing of their children or grandchildren. Results of the two-year study at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) appear in the December issue of the journal Genetics in Medicine. The data could lead to the establishment of formal, evidence-based guidelines for genetic testing of people younger than 18 years.

Genetic variants may affect risk of breast cancer
An international study led by researchers at Memorial Sloan-Kettering Cancer Center has identified genetic variants in women with BRCA2 mutations that may increase or decrease their risk of developing breast cancer.

Preventive surgeries better in breast or ovarian cancer patients
A long-term study of women with a genetic predisposition for breast or ovarian cancer showed that those who elected major preventive surgeries had a significantly reduced risk of those cancers.

Brothers of prostate cancer patients undergo more diagnostic activities
The brothers of men with prostate cancer are at an increased risk of prostate cancer diagnosis because of increased diagnostic activity and not necessarily because they carry a genetic mutation that increases risk of the disease, according to a study published online August 19 in The Journal of the National Cancer Institute.

Molecular mechanism triggering Parkinson's disease identified
Scientists at the Stanford University School of Medicine have identified a molecular pathway responsible for the death of key nerve cells whose loss causes Parkinson's disease. This discovery not only may explain how a genetic mutation linked to Parkinson's causes the cells' death, but could also open the door to new therapeutic approaches for the malady.

Vitamin B6 lowers risk of lung cancer
An analysis that included nearly 400,000 participants finds that those with higher blood levels of vitamin B6 and the essential amino acid methionine (found in most protein) had an associated lower risk of lung cancer, including participants who were current or former smokers.

Genes and Pesticide Exposure increases Parkinson's Disease risk
Genetic mutations and workplace exposure to some insecticides together appear to be associated with an increased risk for Parkinson's disease among men, according to a report in the June issue of Archives of Neurology, one of the JAMA/Archives journals.

Gene mutations lead to autism and mental retardation
Researchers working with Professor Gudrun Rappold, Director of the Department of Molecular Human Genetics at Heidelberg University Hospital, have discovered previously unknown mutations in autistic and mentally impaired patients in what is known as the SHANK2 gene, a gene that is partially responsible for linking nerve cells. However, a single gene mutation is not always enough to trigger the illness.

New gene in hair loss identified
A team of investigators from Columbia, Rockefeller and Stanford Universities has identified a new gene involved in hair growth, as reported in a paper in the April 15 issue of Nature.

MRI detects breast cancer at earlier stage
Magnetic resonance imaging (MRI) coupled with mammography detects almost all cancers at an early stage, thereby reducing the incidence of advanced stage breast cancer in high-risk women.

Researchers decoded genetic evolution of a breast cancer tumour
Canadian researchers have decoded all of the three billion letters in the DNA sequence of a metastatic lobular breast cancer tumor, a type of breast cancer which accounts for about 10 per cent of all breast cancers.

Women opt surgery to remove breasts, ovaries to reduce cancer risk
Many women at high risk for breast or ovarian cancer are choosing to undergo surgery as a precautionary measure to decrease their cancer risk, revealed by US researchers.

Breast cells responsible for breast cancers
Breast cells called luminal progenitor cells are likely to be responsible for breast cancers that develop in women carrying mutations in the gene BRCA1, revealed by researchers.

ABCG2 gene mutation causes gout
Johns Hopkins scientists out a gene for gout - ABCG2 gene mutation is responsible for causing the joint inflammation and pain that are symptoms of gout.

Genetic code mistake causes ovarian cancer
Eureka! Vancouver scientists from the Ovarian Cancer Research (OvCaRe) Program at BC Cancer Agency and Vancouver Coastal Health Research Institute have discovered that there appears to be a single spelling mistake in the genetic code of granulosa cell tumours, a rare and often untreatable form of ovarian cancer.

Zebrafish provide a model for cancerous melanoma in humans
In a new study published in Disease Models & Mechanisms, scientists use the zebrafish to gain insight into the influence of known cancer genes on the development and progression of melanoma, an aggressive form of human skin cancer with limited treatment options.

A breakthrough in floppy baby syndrome research
In a world first, West Australian scientists have cured mice of a devastating muscle disease that causes a Floppy Baby Syndrome – a breakthrough that could ultimately help thousands of families across the globe.

AMP joins ACLU to challenge BRCA gene patents
The Association for Molecular Pathology (AMP) announced that it is working with the American Civil Liberties Union (ACLU) and the Public Patent Foundation to bring a lawsuit charging that patents on two human genes associated with breast and ovarian cancer are unconstitutional and should be invalidated.

$51 million for cancer research in US
The American Cancer Society, the largest non-government, not-for-profit funding source of cancer research in the United States, has awarded 143 national research and training grants totaling more than $51 million in the second of two grant cycles for 2009. The grants go into effect beginning July 1, 2009.

Major advance in stem cell reprogramming technology
In a paper publishing online April 23rd in Cell Stem Cell, a Cell Press journal, Dr. Sheng Ding and colleagues from the Scripps Research Institute in La Jolla, California, report an important step forward in the race to make reprogrammed stem cells that may be better suited for use in clinical settings.

Melanoma skin cancer triggered by BRAF gene mutation
Up to 70 per cent of melanoma skin cancers could be triggered by a particular genetic mutation, according to a study by The Institute of Cancer Research (ICR) published in Cancer.

New cancer gene UTX identified
Researchers have identified a new cancer gene - one that is common to many cancers and affects the most basic regulation of our genes.

Women with BRCA mutation most likely to undergo mastectomy
Women at increased risk for breast cancer because of the genetic BRCA mutations are more likely to think a prophylactic mastectomy is the best way to reduce their risk for the disease, compared to other women who are at high risk, according to researchers at The University of Texas M. D. Anderson Cancer Center.

Gene mutations cause childhood brain cancer medulloblastoma
Researchers funded by the Canadian Cancer Society have discovered eight similar genes that, when mutated, appear to be responsible for medulloblastoma – the most common of childhood brain cancers.

Brain cancer malignant glioma linked to gene mutations
Scientists at Duke University Medical Center and Johns Hopkins University have discovered mutations in two genes that could become therapeutic targets in malignant glioma, a dangerous class of brain tumors.

New genes identified linked to lung cancer
Working as part of a multi-institutional collaboration, scientists at Washington University School of Medicine in St. Louis have assembled the most complete catalog to date of the genetic changes underlying the most common form of lung cancer.

Exercise reduces obesity risk in genetically predisposed
Individuals who have a genetic mutation associated with high body mass index (BMI) may be able to offset their increased risk for obesity through physical activity, according to a report in the September 8 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

A genetic trait identified for colorectal cancer risk
Scientists at Northwestern University's Feinberg School of Medicine and colleagues have discovered a genetic trait that is present in 10 to 20 percent of patients with colorectal cancer. The findings strongly suggest that the trait is a major contributor to colorectal cancer risk and likely the most common cause of colorectal cancer to date.

International Cancer Genome Consortium sets sights on cancer
The International Cancer Genome Consortium (ICGC), which includes the Wellcome Trust and the Wellcome Trust Sanger Institute in the UK, will generate a valuable resource enabling the development of new and better ways of diagnosing, treating and preventing cancer.

Gene mutations may extend human life span
Mutations in genes governing an important cell-signaling pathway influence human longevity, scientists at the Albert Einstein College of Medicine of Yeshiva University have found. Their research is described in the March 4 issue of the Proceedings of the National Academy of Sciences.

Alcohol intake may increase blood pressure
The relationship between heavy drinking and hypertension is more significant than previously thought according to a new analysis of recent studies by researchers at Bristol University, published in PLoS Medicine.

IGFBP7 protein may stop melanoma skin cancer
Howard Hughes Medical Institute (HHMI) researchers have uncovered a protein that stops the growth of melanoma, a cancer that develops from pigment-producing cells in the skin called melanocytes.

Genetic mutation increases risk of preterm birth
Genetic mutations in the Toll-like receptor 4 (TLR4) gene appear to have significant association with inflammatory injury to the placenta and developing baby, researchers from the University of Pittsburgh's department of obstetrics, gynecology and reproductive sciences report at the 28th annual meeting of the Society for Maternal-Fetal Medicine. Scientific sessions continue through Saturday, Feb. 2, at the Dallas Hyatt Regency at Reunion.

Changes in X chromosome may lead to mental retardation
University of Adelaide geneticist Dr Jozef Gecz and a team of Belgium and UK scientists have achieved a major breakthrough in discovering the causes of intellectual disability. Dr Gecz, a senior researcher who is based at the Women's and Children's Hospital in Adelaide, has collaborated with an international research team to reveal that various mutations of a small part of the X chromosome lead to mental retardation.

Genes linked with lupus giving hope for new treatments
Scientists have identified a number of genes involved in Lupus, a devastating autoimmune disease, in new research published today in the journal Nature Genetics. In an international genetic study of more than 3,000 women, researchers found evidence of an association between Lupus (systemic lupus erythematosus or SLE) and mutations in several different genes.

Brain imaging and genetic studies link thinking patterns to addiction
Alcoholics are more impulsive than non-addicted people making financial decisions, revealed by researcher Charlotte Boettiger at the University of North Carolina at Chapel Hill.

Breast cancer gene mutation common in Hispanic, young black women
A genetic mutation already known to be more common in Ashkenazi Jewish breast cancer patients is also prevalent in Hispanic and young African-American women with breast cancer, according to one of the largest, multiracial studies of the mutation to date.

Gene changes may lead to hardening of arteries, atherosclerosis
Researchers revealed that changes in gene may lead to hardening of the arteries and expands lesions in the aorta and promotes coronary atherosclerosis. The study was done by researchers from Yale School of Medicine and published in Cell Metabolism.

48 Gene Mutation articles listed above.

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