Genome



Genome is the total genetic content contained in a haploid set of chromosomes in eukaryotes, in a single chromosome in bacteria, or in the DNA or RNA of viruses.


Genome - most related articles:

- Genome 10K - to sequence 10000 vertebrates - 4.1
- Human Genome Sequencing decoded in India - 3.3
- Schistosomiasis parasite's Schistosoma mansoni's Genome decoded - 3.2
- 4 new risk factors for prostate cancer - deCODE genetics - 2.9
- Chromosomal abnormalities play substantial role in autism - 2.8
- 1000 Genomes Project to support disease studies - 2.6
- Whole genome breast cancer study launched by Mayo Clinic USA - 2.6
- 2 new locations of genes causing multiple sclerosis - 2.5
- International Cancer Genome Consortium sets sights on cancer - 2.5
- 95 genetic variants linked to cholesterol, triglycerides - 2.3

Genome articles

Violence during childhood may impact kids' DNA
Children who have experienced violence might really be older than their years. The DNA of 10-year-olds who experienced violence in their young lives has been found to show wear and tear normally associated with aging, a Duke University study has found.

Whole genome breast cancer study launched by Mayo Clinic USA
The Breast Cancer Genome Guided Therapy Study (BEAUTY Project) will help physicians tailor chemotherapy to breast cancer patients based on their individual genomes and the genomes of their tumors.

Reversing Alzheimer's gene blockade can restore memory
MIT neuroscientists have shown that an enzyme overproduced in the brains of Alzheimer's patients creates a blockade that shuts off genes necessary to form new memories. Furthermore, by inhibiting that enzyme in mice, the researchers were able to reverse Alzheimer's symptoms.

Genes identified causing antimalarial drug resistance
Using a pair of powerful genome-search techniques, researchers from the Harvard School of Public Health (HSPH), Harvard University, and the Broad Institute have identified several genes that may be implicated in the malaria parasite's notorious ability to rapidly evade drug treatments.

New Parkinson's gene is linked to immune system
A hunt throughout the human genome for variants associated with common, late-onset Parkinson's disease has revealed a new genetic link that implicates the immune system and offers new targets for drug development.

95 genetic variants linked to cholesterol, triglycerides
Researchers have discovered or confirmed 95 regions of the human genome where genetic variants are associated with blood cholesterol and triglyceride levels, which are major indicators of heart disease risk.

Genetic variants may make people susceptible to autism disorder
Autism is caused in part by rare genetic changes called copy number variants (CNVs), revealed by an international consortium of researchers from more than 70 universities, including the University of Utah.

New gene linked to Alzheimer's disease
Researchers have identified a gene that appears to increase a person's risk of developing late-onset Alzheimer's disease, the most common type of Alzheimer's disease.

Genomic sequencing of difficult breast cancers
Life Technologies Corporation (NASDAQ: LIFE) announced that it is collaborating with the Translational Genomics Research Institute (TGen) and US Oncology to sequence the genomes of 14 patients afflicted with triple negative breast cancer whose tumors have progressed despite multiple other therapies.

Leprosy susceptibility genes reported in a genome study
In the first genome-wide association study (GWAS) of leprosy and the largest GWAS on an infectious disease, scientists at the Genome Institute of Singapore (GIS) and 26 institutes in China identified seven genes that increase an individual's susceptibility to leprosy.

New genes for lung disease discovered
Scientists have discovered five genetic variants that are associated with the health of the human lung. The research by an international consortium of 96 scientists from 63 centres in Europe and Australia sheds new light on the molecular basis of lung diseases.

Human Genome Sequencing decoded in India
The Council of Scientific and Industrial Research (CSIR) has achieved completion of first ever Human Genome Sequencing in India. Scientist of CSIR at the Institute of Genomics and Integrative Biology (IGIB), Delhi have sequenced the Human Genome of an anonymous healthy Indian citizen.

Genome 10K - to sequence 10000 vertebrates
An international group of scientists is proposing to generate whole genome sequences for 10,000 vertebrate species using technology so new it hasn't yet been invented.

4 new risk factors for prostate cancer - deCODE genetics
deCODE genetics (Nasdaq:DCGN) announced that a team of its scientists and academic colleagues from Finland, Spain, the Netherlands and the United States have published the discovery of four novel single-letter variations in the sequence of the human genome (SNPs) conferring increased risk of prostate cancer.

Gene variant linked to effectiveness of plavix
Patients with a certain genetic variation and who received the antiplatelet drug clopidogrel -- Plavix -- had a decreased platelet response to treatment, revealed by researchers.

New biomarker predicts response to hepatitis C treatment
Researchers at Duke University Medical Center have identified the first genetic marker that predicts response to hepatitis C treatments, and a single letter of DNA code appears to make a huge difference.

Lupus drug Benlysta effective for SLE patients
Human Genome Sciences, Inc. (Nasdaq: HGSI) and GlaxoSmithKline PLC (GSK) announced that BENLYSTA (belimumab, formerly LymphoStat-B®) met the primary endpoint in BLISS-52, the first of two pivotal Phase 3 trials in patients with serologically active systemic lupus erythematosus (SLE).

Genes linked to blood pressure in African-Americans
Five genetic variants related to blood pressure -- hypertension -- in African-Americans, revealed by a team of researchers from the National Institutes of Health, USA.

Schistosomiasis parasite's Schistosoma mansoni's Genome decoded
Researchers have sequenced the genome of the parasite -- Schistosoma mansoni -- that causes intestinal schistosomiasis (also known as bilharzia or snail fever), a devastating tropical disease that afflicts more than 200 million people in the developing world.

Altered genes play role in development of brain tumors
The interaction between a network of altered genes appears to play an important role in the development and progression of brain tumors, revealed by researchers in the Journal of the American Medical Association -- JAMA.

Schizophrenia linked to common genetic variations
Researchers has discovered that nearly a third of the genetic basis of schizophrenia may be attributed to the cumulative actions of thousands of common genetic variants.

2 new locations of genes causing multiple sclerosis
Two new locations of genes responsible for multiple sclerosis are discovered which will help to unravel the causes of MS and other autoimmune disease, revealed by Australian and New Zealand researchers

Genetic code mistake causes ovarian cancer
Eureka! Vancouver scientists from the Ovarian Cancer Research (OvCaRe) Program at BC Cancer Agency and Vancouver Coastal Health Research Institute have discovered that there appears to be a single spelling mistake in the genetic code of granulosa cell tumours, a rare and often untreatable form of ovarian cancer.

Genes responsible for testicular cancer risk in men
Researchers at the University of Pennsylvania School of Medicine have uncovered variation around two genes that are associated with an increased risk of testicular cancer.

New genomic approaches for treating skin diseases
The health of our skin - one of the body's first lines of defense against illness and injury - depends upon the delicate balance between our own cells and the millions of bacteria and other one-celled microbes that live on its surface.

$24 million for rare and neglected diseases research
The National Institutes of Health is launching the first integrated, drug development pipeline to produce new treatments for rare and neglected diseases. The $24 million program jumpstarts a trans-NIH initiative called the Therapeutics for Rare and Neglected Diseases Program, or TRND.

New lead on malaria treatment
Approximately 350 million to 500 million cases of malaria are diagnosed each year mostly in sub-Saharan Africa. While medications to prevent and treat malaria do exist, the demand for new treatments is on the rise, in part, because malaria parasites have developed a resistance to existing medications.

AMP joins ACLU to challenge BRCA gene patents
The Association for Molecular Pathology (AMP) announced that it is working with the American Civil Liberties Union (ACLU) and the Public Patent Foundation to bring a lawsuit charging that patents on two human genes associated with breast and ovarian cancer are unconstitutional and should be invalidated.

Stroke linked to genetic changes
Scientists have identified a previously unknown connection between two genetic variants and an increased risk of stroke, providing strong evidence for the existence of specific genes that help explain the genetic component of stroke.

Positive results of Albuferon in Chronic Hepatitis C
Human Genome Sciences, Inc. (Nasdaq: HGSI) announced that Albuferon (albinterferon alfa-2b) met its primary endpoint of non-inferiority to peginterferon alfa-2a (Pegasys) in ACHIEVE 1, a Phase 3 clinical trial of Albuferon in combination with ribavirin in treatment-naive patients with genotype 1 chronic hepatitis C (p=0.0008).

Draft version of the Neanderthal genome completed
The Max Planck Institute for Evolutionary Anthropology, in Leipzig, Germany, and the 454 Life Sciences Corporation, in Branford, Connecticut, will announce on 12 February during the 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS) and at a simultaneous European press briefing that they have completed a first draft version of the Neandertal genome.

Obesity starts in the head?
Obesity is known to increase the risk of chronic disorders, such as diabetes (type 2). An international team of scientists with German participation through the Helmholtz Zentrum München identified six new obesity genes.

Few DNA repair genes associated with cancer risk
Variants of numerous DNA repair genes initially appeared to be statistically significantly associated with cancer risk in epidemiological studies.

Hypertension susceptibility gene STK39 identified
Researchers at the University of Maryland School of Medicine have identified a common gene variant that appears to influence people's risk of developing high blood pressure, according to the results of a study being published online Dec. 29, 2008 in the Proceedings of the National Academy of Sciences (PNAS).

New genes identified linked to lung cancer
Working as part of a multi-institutional collaboration, scientists at Washington University School of Medicine in St. Louis have assembled the most complete catalog to date of the genetic changes underlying the most common form of lung cancer.

23andMe announces breast cancer initiative
23andMe, Inc., the industry leader in personal genetics, announced that it is embarking on a world-wide effort to assemble the largest cohort of women whose lives have been impacted by breast cancer and to build an infrastructure, based on genetics, that will accelerate consumer-based research of the disease.

Chromosomal changes increase schizophrenia risk
People with schizophrenia (mental illness variously affecting behavior, thinking, and emotion) have an increased number of unusual chromosomal changes, particularly structural changes that have the potential to alter the function of the genes.

International Cancer Genome Consortium sets sights on cancer
The International Cancer Genome Consortium (ICGC), which includes the Wellcome Trust and the Wellcome Trust Sanger Institute in the UK, will generate a valuable resource enabling the development of new and better ways of diagnosing, treating and preventing cancer.

Conservation of genes may stop aging
A study published online in Genome Research provides new insight into the evolutionary conservation of the genes and pathways associated with aging. This report describes the identification of conserved aging-related genes in simple model organisms that may lead to the characterization of similar genes playing a role in human aging and age-associated diseases.

7 new prostate cancer genetic risk factors identified
7 new sites in the human genome identified that are linked to men's risk of developing prostate cancer, revealed by Cancer Research UK funded scientists at the Institute of Cancer Research and University of Cambridge.

IGFBP7 protein may stop melanoma skin cancer
Howard Hughes Medical Institute (HHMI) researchers have uncovered a protein that stops the growth of melanoma, a cancer that develops from pigment-producing cells in the skin called melanocytes.

Genes linked with lupus giving hope for new treatments
Scientists have identified a number of genes involved in Lupus, a devastating autoimmune disease, in new research published today in the journal Nature Genetics. In an international genetic study of more than 3,000 women, researchers found evidence of an association between Lupus (systemic lupus erythematosus or SLE) and mutations in several different genes.

1000 Genomes Project to support disease studies
An international research consortium announced the 1000 Genomes Project, an ambitious effort that will involve sequencing the genomes of at least a thousand people from around the world to create the most detailed and medically useful picture to date of human genetic variation.

Chromosomal abnormalities play substantial role in autism
Genome-wide scans of families affected by autism spectrum disorder (ASD) have revealed new evidence that previously unknown chromosomal abnormalities have a substantial role in the prevalent developmental disorder, according to a report published online Jan. 17th in the American Journal of Human Genetics, a publication of Cell Press.

44 Genome articles listed above.


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What is Genome
Genome is the total genetic content contained in a haploid set of chromosomes in eukaryotes, in a single chromosome in bacteria, or in the DNA or RNA of viruses.



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