Metabolic Disease

Purple, high anthocyanin tomatoes offer protection against certain cancers
Scientists have expressed genes from snapdragon in tomatoes to grow purple tomatoes high in health-protecting anthocyanins.

Acomplia rimonabant obesity drug withdrawn
Sanofi-aventis announced that the European Medicines Agency (EMEA) has recommended to the European Commission (EC) the temporary suspension of the marketing authorisation of Acomplia(R) (rimonabant) for the approved indication of overweight and obese patients.

Brain pathway responsible for obesity discovered
University of Wisconsin-Madison researchers, for the first time, have found a messaging system in the brain that directly affects food intake and body weight.

Health expert urges FDA to take action to reduce BPA exposure
Researchers found a significant relationship between urine concentrations of the environmental estrogen bisphenol A (BPA) and cardiovascular disease, type 2 diabetes and liver-enzyme abnormalities.

Some obese individuals appear healthy without heart risk
Some obese individuals do not appear to have an increased risk for heart disease, while some normal-weight individuals experience a cluster of heart risks, according to two reports in the August 11/25 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Eyes could serve as early warning of diabetes
A new vision screening device, already shown to give an early warning of eye disease, could give doctors and patients a head start on treating diabetes and its vision complications, a new study shows.

Depression risk high in treated diabetes patients
Persons with treated type 2 diabetes are at increased risk for developing depression, while a more modest association was found between persons with depression and the risk of diabetes, revealed by researchers.

Heart disease predetermined by oxygen levels in the womb
The amount of oxygen available to a baby in the womb can affect their susceptibility to developing particular diseases later in life. Research presented at the annual Society for Endocrinology BES meeting in Harrogate shows that your risk of developing cardiovascular disease can be predetermined before birth, not only by your genes, but also by their interaction with the quality of the environment you experience in the womb.

Obesity in midlife increases dementia risk
People in their 40s with larger stomachs have a higher risk for dementia when they reach their 70s, according to a study published in the March 26, 2008, online issue of Neurology, the medical journal of the American Academy of Neurology.

New chemical tool kit reveals insights into drug toxicity
Why do nearly 1 million people taking cholesterol-lowering statins often experience muscle cramps? Why is it that in the rare case when a diabetic takes medication for intestinal worms, his glucose levels improve? Is there any scientific basis for the purported health effects of green tea?

Safer effective way to treat Crohn's disease
A new study established the new alternative strategy, called "top-down" therapy, to treat the patients with Crohn's disease by employing early use of immune-suppressing drugs combined with an antibody without using steroids.

Most with high blood pressure do not follow DASH diet
A relatively small proportion of individuals with hypertension (high blood pressure) eat diets that align with government guidelines for controlling the disease, according to a report in the February 11 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Weight gain from artificial sweeteners
Use of no-calorie sweeteners may make it harder for people to control their intake and body weight. Cutting the connection between sweets and calories may confuse the body, making it harder to regulate intake, revealed by researchers.

Overweight pregnant women may have fatter children
Mothers-to-be beware. Women who are overweight during pregnancy may be more likely to have fatter children susceptible to chronic health problems, University of New South Wales (UNSW) research shows.

Burgers, fries, diet soda lead to metabolic syndrome
Otherwise-healthy adults who eat two or more servings of meat a day - the equivalent of two burger patties - increase their risk of developing metabolic syndrome by 25 percent compared with those who eat meat twice a week, according to research published in Circulation: Journal of the American Heart Association.

GIP hormone to prevent obesity
A new study finds that a chemical found in the body is capable of promoting weight loss, improving insulin resistance and reversing diabetes in an animal model. The hormone is gastric inhibitory polypeptide (GIP) receptor blockade.

Immune system responsible for increased inflammation in diabetes patients
Researchers at UC Davis Health System have discovered a novel pathway that results in increased inflammation of blood vessels in patients with type 1 diabetes. Their findings suggest that, with good diabetes control, this inflammation may be reduced, possibly resulting in a reduction of cardiovascular disease as well.

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